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Thirty-one patients with coronary artery disease and twenty-six normal subjects underwent 99mTc-GBPS before and aft.er coronary vasodilatation was induced by dipyridamIe 0.54 mg/kg given IV over 4 min. LVKF, EF and regional wall motion by phase analysis were measured during rest and dipyridamole infusion. The results were as follows: 1) Mean LVEF of normal subjects was significantly higher than that of MI group (p=0.001), but similar to that of angina group during rest. Among Ml group, mean LVEF of anterior MI group was significantly lower than that of inferior MI group during rest (p=0,024). 2) The normal subjects had a significnat increase in mean LVEF during dipyridamole infusion (+ 12 +- 3,8), while the CAD group had no increase (+ 2=5.0) (p<0.001). If an increase of LVEF during stress is less than 5%., it suggests an abnormality. The sensitivity and specificity of LUEF changes aft:er dipyridamole infusion were 81%, 96%, respectively. 3) With phase analysis, LV mean phase angle af normal subjects and CAD patients was 143+20, 5, 132 +- 20.6 rc.spectively, durign rest (p=0.049). But an ncrease of LV mean phase angle during dipyridamole infusion in t.hese two groups was not signifieantly different. Dipyridarnole infusion did not affect standard deviation and FWHM of phase angle. 4) Regional wall motion was abnormal in 5 patients (16%) during dipyridamole infusion. 5) Side effects with dipyridamole infusion include; headache, angina pain, chest discomfirt, nausea, weakness sense. In conclusion, dipyridamole GBPS might be useful in detection and follow up of CAD.
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